Vasoconstrictors inhibit ATP-sensitive K+ channels in arterial smooth muscle through protein kinase C.
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Vasoconstrictors Inhibit ATP-sensitive K + Channels in Arterial Smooth Muscle through Protein Kinase C
A B S T RA C T The effects of vasoconstrictor-receptor (neuropeptide Y, a-adrenergic, serotonergic, histaminergic) stimulation on currents through ATP-sensitive potassium (KATe) channels in arterial smooth muscle cells were examined. Whole-cell KAT e currents, activated by the synthetic KAT e channel opener pinacidil or by the endogenous vasodilator, calcitonin gene-related peptide, which acts ...
متن کاملVasoconstrictors inhibit ATP-sensitive K+ channels in arterial smooth muscle through protein kinase C
The effects of vasoconstrictor-receptor (neuropeptide Y, alpha-adrenergic, serotonergic, histaminergic) stimulation on currents through ATP-sensitive potassium (KATP) channels in arterial smooth muscle cells were examined. Whole-cell KATP currents, activated by the synthetic KATP channel opener pinacidil or by the endogenous vasodilator, calcitonin gene-related peptide, which acts through prote...
متن کاملAngiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels.
OBJECTIVE The vasoconstrictor angiotensin II (Ang II) acts at G(q/11)-coupled receptors to suppress ATP-sensitive potassium (K(ATP)) channel activity via activation of protein kinase C (PKC). The aim of this study was to determine the PKC isoforms involved in the Ang II-induced inhibition of aortic K(ATP) channel activity and to investigate potential mechanisms by which these isoforms specifica...
متن کاملCalcium modulation of vascular smooth muscle ATP-sensitive K(+) channels: role of protein phosphatase-2B.
ATP-sensitive K(+) (K(ATP)) channels are broadly distributed in the vasculature and regulate arterial tone. These channels are inhibited by intracellular ATP ([ATP](i)) and vasoconstrictor agents and can be activated by vasodilators. It is widely assumed that K(ATP) channels are insensitive to Ca(2+), although regulation has not been examined in the intact cell where cytosolic regulatory proces...
متن کاملProtein kinase C isoform-dependent modulation of ATP-sensitive K+ channels in mitochondrial inner membrane.
The ATP-sensitive K(+) (K(ATP)) channels in both sarcolemmal (sarcK(ATP)) and mitochondrial inner membrane (mitoK(ATP)) are the critical mediators in cellular protection of ischemic preconditioning (IPC). Whereas cardiac sarcK(ATP) contains Kir6.2 and sulfonylurea receptor (SUR)2A, the molecular identity of mitoK(ATP) remains elusive. In the present study, we tested the hypothesis that protein ...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1996
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.108.4.315